Orchestrating the Organizers: Lymphotoxin-β Receptor Conducts Fibroblastic Reticular Cell Maturation

Fibroblastic Reticular Cells: Organization

Influence of the Fibroblastic Reticular Network on Cell-Cell Interactions in Lymphoid Organs

Secondary lymphoid organs (SLO), such as lymph nodes and the spleen, display a complex micro-architecture. In the T cell zone the micro-architecture is provided by a network of fibroblastic reticular cells (FRC) and their filaments. The FRC network is thought to enhance the interaction between immune cells and their cognate antigen. However, the effect of the FRC network on cell interaction can...

Lymphotoxin β Receptor Controls T Cell Progenitor Entry to the Thymus

The recruitment of lymphoid progenitors to the thymus is essential to sustain T cell production throughout life. Importantly, it also limits T lineage regeneration following bone marrow transplantation, and so contributes to the secondary immunodeficiency that is caused by delayed immune reconstitution. Despite this significance, the mechanisms that control thymus colonization are poorly unders...

Fibroblastic reticular cell sarcoma of the small intestine: a very rare case report and clinicopathological diagnosis

A 54-year-old man was referred to our hospital because of abdominal pain and fever. According to the principle of Occam’s Razor, we needed to find an inflammatory or neoplastic etiology to explain both symptoms. The patient had been healthy until 3 months before admission. He had intermittent colic around the umbilicus with exacerbation after eating. The patient rated his pain 6–10 on a 10-poin...

Lymphotoxin β receptor signaling promotes development of autoimmune pancreatitis.

BACKGROUND & AIMS Little is known about the pathogenic mechanisms of autoimmune pancreatitis (AIP), an increasingly recognized, immune-mediated form of chronic pancreatitis. Current treatment options are limited and disease relapse is frequent. We investigated factors that contribute to the development of AIP and new therapeutic strategies. METHODS We used quantitative polymerase chain reacti...